UZ Leuven

New evidence on the reliability and validity of the Pediatric Oncology Quality of Life Scale. Bijttebier P, Vercruysse T, Vertommen H, Van Gool S, Uyttebroeck A, Brock P. Psychology and Health 2001;16:461-469. Claes E, Evers-Kiebooms G, Denayer L, Decruyenaere M, Boogaerts A, Philippe K, Legius E. Predictive genetic testing for hereditary breast and ovarian cancer: psychological distress and illness representations one year following disclosure. J Genet Couns 2005;14(5):349-63.Abstract: This prospective study evaluates emotional functioning and illness representations in 68 unaffected women (34 carriers/34 noncarriers) 1 year after predictive testing for BRCA1/2 mutations when offered within a multidisciplinary approach. Carriers had higher subjective risk perception of breast cancer than noncarriers. Carriers who did not have prophylactic oophorectomy had the highest risk perception of ovarian cancer. No differences were found between carriers and noncarriers regarding perceived seriousness and perceived control of breast and ovarian cancer. Mean levels of distress were within normal ranges. Only few women showed an overall pattern of clinically elevated distress. Cancer-specific distress and state-anxiety significantly decreased in noncarriers from pre- to posttest while general distress remained about the same. There were no significant changes in distress in the group of carriers except for ovarian cancer distress which significantly decreased from pre- to posttest. Our study did not reveal adverse effects of predictive testing when offered in the context of a multidisciplinary approach.

Predictieve genetische tests en hun psychologische betekenis. Evers-Kiebooms G. Die ziekte in mijn familie, krijg ik die later ook?  Raymaekers B, Van Riel G. (Eds) Weten in woorden en daden. Lessen voor de eenentwintigste eeuw. Lessen voor de XXI eeuw, Volume XII, Universitaire Pers Leuven 2006: 61-91.

Attention and information processing in survivors of childhood acute lymphoblastic leukaemia treated with chemotherapy only. Mennes M, Stiers P, Vandenbussche E, Vercruysse G, Uyttebroeck A, De Meyer G, Van Gool SW. Pediatr Blood Cancer 2005;44:479-486. Abstract: BACKGROUND: Omitting radiotherapy for central nervous system (CNS) prophylaxis has improved the overall quality of life for long-term survivors of childhood acute lymphoblastic leukemia (ALL). However, recent reports suggest minor cognitive impairment in survivors who received chemotherapy only. PROCEDURE: This study focused on attentional functioning and speed of information processing in 23 children previously treated for ALL according to EORTC 58881 and EORTC 58951 protocol. Patients received intrathecal methotrexate combined with high doses intravenous methotrexate as CNS prophylaxis. Cognitive functioning was assessed with the Amsterdam Neuropsychological Tasks, a computerized attention assessment program. Variables of both speed and accuracy of the patients were compared with those obtained from 23 age- and sexmatched control children. RESULTS: Patients were equal to control children concerning baseline speed, sustained attention, response inhibition, and response organization. However, they were significantly slower than controls in three tasks: encoding, memory search letters, and focused attention 4-letters. Interactions with the difficulty of the task were found. There were no differences in number or type of errors between groups on all tasks. CONCLUSIONS: ALL survivors treated with chemotherapy have specific information processing difficulties. They process information slower than control children, especially when more information has to be processed or when attention has to be focused precisely. In spite of being slower, patients are equally accurate compared to control children. 2004 Wiley-Liss, Inc.

Opvang van familiale beenmergdonoren binnen de kinderoncologie: hoe ver staan wij? Vercruysse T. Oncologisch tijdschrift 2001;18(4):57-59.

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